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Research
Nasopharyngeal carcinoma (NPC) is a major head and neck cancer with high occurrence in Southeast Asia and southern China. We aimed to identify autoantibodies that may contribute to early detection of NPC.
Clinical Proteomics 2017 14:6
Published on: 1 February 2017
Research
Detection of low-abundance biomarkers using mass spectrometry (MS) is often hampered by non-target molecules in biological fluids. In addition, current procedures for sample preparation increase sample consump...
Clinical Proteomics 2017 14:5
Published on: 19 January 2017
Research
Kallikrein 9 (KLK9) is a member of the human kallikrein-related peptidases family, whose physiological role and implications in disease processes remain unclear. The active form of the enzyme is predicted to h...
Clinical Proteomics 2017 14:4
Published on: 17 January 2017
Research
Glycans play critical roles in a number of biological activities. Two common types of glycans, N-linked and O-linked, have been extensively analyzed in the last decades. N-glycans are typically released from g...
Clinical Proteomics 2017 14:3
Published on: 13 January 2017
Research
sIgE and sIgG4 detection is necessary for more accurate and effective type I hypersensitivity diagnostics and the estimation of disease development. Typically, the analyses of these antibodies are performed se...
Clinical Proteomics 2017 14:1
Published on: 9 January 2017
Research
Autism is a severe childhood neurological disorder with poorly understood etiology and pathology. Currently, there is no authentic laboratory test to confirm the diagnosis of autism. Oxidative damage may play ...
Clinical Proteomics 2017 14:2
Published on: 9 January 2017
Review
Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past decade, proteomics applications can now go beyond ...
Clinical Proteomics 2016 13:23
Published on: 5 December 2016
Research
Excretory-secretory (ES) proteins of E. histolytica are thought to play important roles in the host invasion, metabolism, and defence. Elucidation of the types and functions of E. histolytica ES proteins can furt...
Clinical Proteomics 2016 13:33
Published on: 22 November 2016
Research
High quality clinical samples are critical for meaningful interpretation of data obtained in both basic and translational medicine. More specifically, optimized pre-analysis handling to bio-sample is crucial ...
Clinical Proteomics 2016 13:34
Published on: 22 November 2016
Research
Ovarian cancer is the most lethal gynecological malignancy due to its frequent recurrence and drug resistance even after successful initial treatment. Accumulating scientific evidence indicates that subpopulat...
Clinical Proteomics 2016 13:32
Published on: 10 November 2016
Review
Proteomics has emerged as a highly promising bioanalytical technique in various aspects of applied biological research. In Indian academia, proteomics research has grown remarkably over the last decade. It is ...
Clinical Proteomics 2016 13:21
Published on: 5 November 2016
Research
Lung cancer is the leading cause of cancer mortality in the United States. Non-small cell lung cancer accounts for 85% of all lung cancers for which adenocarcinoma is the most common histological type. Managem...
Clinical Proteomics 2016 13:31
Published on: 27 October 2016
Research
Correct identification of the amyloidosis-causing protein is crucial for clinical management. Recently the Mayo Clinic reported laser-capture microdissection (LCM) with liquid chromatography-coupled tandem mas...
Clinical Proteomics 2016 13:30
Published on: 27 October 2016
Research
Retinoblastoma is an ocular neoplastic cancer caused primarily due to the mutation/deletion of RB1 gene. Due to the rarity of the disease very limited information is available on molecular changes in primary r...
Clinical Proteomics 2016 13:29
Published on: 26 October 2016
Research
Early recurrence after surgical resection is a hallmark of poor prognosis in hepatocellular carcinoma (HCC). To determine the proteomic background of early recurrence of HCC, we focused on apoptosis-related pr...
Clinical Proteomics 2016 13:28
Published on: 24 October 2016
Research
Diabetic nephropathy (DN) is a late complication in both type 1 diabetes mellitus (T1DM) and T2DM. Already at an early stage of DN morphological changes occur at the cell surface and in the extracellular matri...
Clinical Proteomics 2016 13:22
Published on: 15 October 2016
Research
Fibrinogen alpha C chain 5.9 kDa fragment (FIC5.9) is a new serum biomarker for chronic hepatitis that was discovered by proteomics analysis. Previous studies have shown that FIC5.9 is derived from the C-termi...
Clinical Proteomics 2016 13:27
Published on: 7 October 2016
Review
Mass spectrometry-based proteomics methodology has become an important tool in elucidating some of the underlying mechanisms involved in cardiovascular disease. The present review provides details on selected ...
Clinical Proteomics 2016 13:20
Published on: 5 October 2016
Review
Disease progression and drug response may vary significantly from patient to patient. Fortunately, the rapid development of high-throughput ‘omics’ technologies has allowed for the identification of potential ...
Clinical Proteomics 2016 13:25
Published on: 26 September 2016
Research
The successful application of—omics technologies in the discovery of novel biomarkers and targets of therapeutic interventions is facilitated by large collections of well curated clinical samples stored in bio...
Clinical Proteomics 2016 13:26
Published on: 26 September 2016
Research
Non-invasive monitoring of liver disease remains an important health issue. Liver secreted glycoproteins reflect pathophysiological states of the organ and represent a rational target for serologic monitoring....
Clinical Proteomics 2016 13:24
Published on: 21 September 2016
Review
Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of cardiac wound healing responses that involve stimulation of robust inflammation to clear necrotic myocytes and tissue debris...
Clinical Proteomics 2016 13:19
Published on: 15 September 2016
Research
Ebola virus like particles (EBOV VLPs, eVLPs), are produced by expressing the viral transmembrane glycoprotein (GP) and structural matrix protein VP40 in mammalian cells. When expressed, these proteins self-a...
Clinical Proteomics 2016 13:18
Published on: 5 September 2016
Research
The urinary proteome of patients undergoing cardiopulmonary bypass (CPB) may provide important insights into systemic and renal changes associated with the procedure. Such information may ultimately provide a ...
Clinical Proteomics 2016 13:17
Published on: 15 August 2016
Research
Angiotensin-II (Ang II) mediates progression of autosomal-dominant polycystic kidney disease (ADPKD) and other chronic kidney diseases (CKD). However, markers of kidney Ang II activity are lacking. We previous...
Clinical Proteomics 2016 13:16
Published on: 5 August 2016
Clinical Proteomics is affiliated with the Human Proteome Organization (HUPO). HUPO is an international scientific organization representing and promoting proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training.
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