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  1. Content type: Research

    In the assisted reproduction, the infertile molecules of spermatozoa from normozoospermic men who underwent the unexplained failure of in vitro fertilization (IVF) due to the lack of sperm binding to the norma...

    Authors: Xin Liu, Gensheng Liu, Juan Liu, Peng Zhu, Jiahui Wang, Yanwei Wang, Wenting Wang, Ning Li, Xuebo Wang, Chenglin Zhang, Xiaofang Shen and Fujun Liu

    Citation: Clinical Proteomics 2018 15:27

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  2. Content type: Research

    Mass spectrometry-based proteomics has become a powerful tool for the identification and quantification of proteins from a wide variety of biological specimens. To date, the majority of studies utilizing tissu...

    Authors: Paul D. Piehowski, Vladislav A. Petyuk, Ryan L. Sontag, Marina A. Gritsenko, Karl K. Weitz, Thomas L. Fillmore, Jamie Moon, Hala Makhlouf, Rodrigo F. Chuaqui, Emily S. Boja, Henry Rodriguez, Jerry S. H. Lee, Richard D. Smith, Danielle M. Carrick, Tao Liu and Karin D. Rodland

    Citation: Clinical Proteomics 2018 15:26

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  3. Content type: Research

    Renal oncocytomas (ROs) are benign epithelial tumors of the kidney whereas chromophobe renal cell carcinoma (chRCCs) are malignant renal tumors. The latter constitute 5–7% of renal neoplasias. ROs and chRCCs s...

    Authors: Vanessa Drendel, Bianca Heckelmann, Christoph Schell, Lucas Kook, Martin L. Biniossek, Martin Werner, Cordula A. Jilg and Oliver Schilling

    Citation: Clinical Proteomics 2018 15:25

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  4. Content type: Research

    Advances in mass spectrometry have accelerated biomarker discovery in many areas of medicine. The purpose of this study was to compare two mass spectrometry (MS) methods, isobaric tags for relative and absolut...

    Authors: Antti Jylhä, Janika Nättinen, Ulla Aapola, Alexandra Mikhailova, Matti Nykter, Lei Zhou, Roger Beuerman and Hannu Uusitalo

    Citation: Clinical Proteomics 2018 15:24

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  5. Content type: Research

    Lower urinary tract symptoms (LUTS) and prostate specific antigen-based parameters seem to have only a limited utility for the differential diagnosis of prostate cancer (PCa). MALDI-TOF/MS peptidomic profiling...

    Authors: Andrea Padoan, Daniela Basso, Carlo-Federico Zambon, Tommaso Prayer-Galetti, Giorgio Arrigoni, Dania Bozzato, Stefania Moz, Filiberto Zattoni, Rino Bellocco and Mario Plebani

    Citation: Clinical Proteomics 2018 15:23

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  6. Content type: Letter to the Editor

    CD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion, signal transduction and cytoskeleton remodelling. It is also one of the most studied glycoproteins in cancer, frequently ex...

    Authors: Rita Azevedo, Cristiana Gaiteiro, Andreia Peixoto, Marta Relvas-Santos, Luís Lima, Lúcio Lara Santos and José Alexandre Ferreira

    Citation: Clinical Proteomics 2018 15:22

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  7. Content type: Research

    Cancer-associated fibroblasts (CAFs) are one of the most important components of tumor stroma and play a key role in modulating tumor growth. However, a mechanistic understanding of how CAFs communicate with t...

    Authors: Xinyan Wu, Muhammad Saddiq Zahari, Santosh Renuse, Nandini A. Sahasrabuddhe, Raghothama Chaerkady, Min-Sik Kim, Mary Jo Fackler, Martha Stampfer, Edward Gabrielson, Saraswati Sukumar and Akhilesh Pandey

    Citation: Clinical Proteomics 2018 15:21

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    The Correction to this article has been published in Clinical Proteomics 2018 15:37

  8. Content type: Research

    Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposi...

    Authors: Neserin Ali, Stefan Ljunggren, Helen M. Karlsson, Aneta Wierzbicka, Joakim Pagels, Christina Isaxon, Anders Gudmundsson, Jenny Rissler, Jörn Nielsen, Christian H. Lindh and Monica Kåredal

    Citation: Clinical Proteomics 2018 15:20

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  9. Content type: Research

    Semen cryopreservation has been widely applied in assisted reproductive technologies and sperm bank, but it causes considerable impairments on sperm quality. It is necessary to find an evaluation indicator for...

    Authors: Ai-jie Xin, Yan-cheng Wu, Hui Lu, Li Cheng, Yi-hua Gu, Hua Diao, Guo-wu Chen, Bin Wu, Zheng Li, Sheng-ce Tao, Xiao-xi Sun and Hui-juan Shi

    Citation: Clinical Proteomics 2018 15:19

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  10. Content type: Research

    The development of clinically accessible biomarkers is critical for the early diagnosis of gastric cancer (GC) in patients. High-throughput proteomics techniques could not only effectively generate a serum pep...

    Authors: Feiyu Shi, Hong Wu, Kai Qu, Qi Sun, Fanni Li, Chengxin Shi, Yaguang Li, Xiaofan Xiong, Qian Qin, Tianyu Yu, Xin Jin, Liang Cheng, Qingxia Wei, Yingchao Li and Junjun She

    Citation: Clinical Proteomics 2018 15:18

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  11. Content type: Research

    The application of advanced imaging technologies for identifying pancreatic cysts has become widespread. However, accurately differentiating between low-grade dysplasia (LGD), high-grade dysplasia (HGD), and ...

    Authors: Misol Do, Dohyun Han, Joseph Injae Wang, Hyunsoo Kim, Wooil Kwon, Youngmin Han, Jin-Young Jang and Youngsoo Kim

    Citation: Clinical Proteomics 2018 15:17

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  12. Content type: Research

    Colorectal cancer is the third most common and the fourth most lethal cancer in the world. In the majority of cases, patients are diagnosed at an advanced stage or even metastatic, thus explaining the high mor...

    Authors: Anaïs Chauvin, Chang-Shu Wang, Sameh Geha, Perrine Garde-Granger, Alex-Ane Mathieu, Vincent Lacasse and François-Michel Boisvert

    Citation: Clinical Proteomics 2018 15:16

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  13. Content type: Research

    Colorectal cancer (CRC) remains a major cause of cancer fatalities in developed countries. The risk of death is correlated to the stage of CRC during the primary diagnosis. Early diagnosis is closely associate...

    Authors: Julien Peltier, Jean-Pierre Roperch, Stéphane Audebert, Jean-Paul Borg and Luc Camoin

    Citation: Clinical Proteomics 2018 15:15

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  14. Content type: Research

    Red blood cell (RBC) physiology is directly linked to many human disorders associated with low tissue oxygen levels or anemia including chronic obstructive pulmonary disease, congenital heart disease, sleep ap...

    Authors: Haddy K. S. Fye, Paul Mrosso, Lesley Bruce, Marie-Laëtitia Thézénas, Simon Davis, Roman Fischer, Gration L. Rwegasira, Julie Makani and Benedikt M. Kessler

    Citation: Clinical Proteomics 2018 15:14

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  15. Content type: Research

    MAP kinase inhibitor (MAPKi) therapy for BRAF mutated melanoma is characterized by high response rates but development of drug resistance within a median progression-free survival (PFS) of 9–12 months. Underst...

    Authors: Nina Zila, Andrea Bileck, Besnik Muqaku, Lukas Janker, Ossia M. Eichhoff, Phil F. Cheng, Reinhard Dummer, Mitchell P. Levesque, Christopher Gerner and Verena Paulitschke

    Citation: Clinical Proteomics 2018 15:13

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  16. Content type: Research

    Preoperative treatment of anti-vascular endothelial growth factor (VEGF) agents is extensively used in proliferative diabetic retinopathy (PDR), but the molecular mechanism is not fully understood. The objecti...

    Authors: Chen Zou, Changjing Han, Minjie Zhao, Jingjing Yu, Lin Bai, Yuan Yao, Shuaixin Gao, Hui Cao and Zhi Zheng

    Citation: Clinical Proteomics 2018 15:12

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  17. Content type: Research

    Proteomic analyses of clinical specimens often rely on human tissues preserved through formalin-fixation and paraffin embedding (FFPE). Minimal sample consumption is the key to preserve the integrity of pathol...

    Authors: Melanie Christine Föll, Matthias Fahrner, Victor Oginga Oria, Markus Kühs, Martin Lothar Biniossek, Martin Werner, Peter Bronsert and Oliver Schilling

    Citation: Clinical Proteomics 2018 15:11

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  18. Content type: Research

    Metabolic diseases such as obesity and diabetes are associated with changes in high-density lipoprotein (HDL) particles, including changes in particle size and protein composition, often resulting in abnormal ...

    Authors: Prahlad K. Rao, Kate Merath, Eugene Drigalenko, Avinash Y. L. Jadhav, Richard A. Komorowski, Matthew I. Goldblatt, Anand Rohatgi, Mark A. Sarzynski, Samer Gawrieh and Michael Olivier

    Citation: Clinical Proteomics 2018 15:10

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  19. Content type: Research

    Carcinoembryonic antigen (CEA) is a glycoprotein associated with colorectal cancer (CRC). While the functions of its gene and protein have been fully characterized, its post-translational modifications in the ...

    Authors: Qianqian Zhao, Tiancheng Zhan, Zaian Deng, Qianqian Li, Yaming Liu, Shaojie Yang, Dengbo Ji and Yan Li

    Citation: Clinical Proteomics 2018 15:9

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  20. Content type: Research

    Our previous studies indicated that miR-200b inhibits the growth of androgen-independent prostate cancer (AIPC) cells. In this study, we employed quantitative proteomics techniques to unravel the role of miR-...

    Authors: Minyi He, Mengzhuang Gou, Min Qi, Wei Xiang, Zhicheng Ji, Wen-Jie Wang, Shan-Chao Zhao and Yawei Liu

    Citation: Clinical Proteomics 2018 15:8

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  21. Content type: Review

    The concept of antibody microarrays is one of the most versatile approaches within multiplexed immunoassay technologies. These types of arrays have increasingly become an attractive tool for the exploratory de...

    Authors: Ziqing Chen, Tea Dodig-Crnković, Jochen M. Schwenk and Sheng-ce Tao

    Citation: Clinical Proteomics 2018 15:7

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  22. Content type: Research

    Scrub typhus is an acute and febrile infectious disease caused by the Gram-negative α-proteobacterium Orientia tsutsugamushi from the family Rickettsiaceae that is widely distributed in Northern, Southern and Ea...

    Authors: Edmond Changkyun Park, Sang-Yeop Lee, Sung Ho Yun, Chi-Won Choi, Hayoung Lee, Hyun Seok Song, Sangmi Jun, Gun-Hwa Kim, Chang-Seop Lee and Seung Il Kim

    Citation: Clinical Proteomics 2018 15:6

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  23. Content type: Research

    Primary membranous nephropathy (PMN) is an important cause of nephrotic syndrome in adults. Urine proteome may provide important clues of pathophysiological mechanisms in PMN. In the current study, we analyzed...

    Authors: Lu Pang, Qianqian Li, Yan Li, Yi Liu, Nan Duan and Haixia Li

    Citation: Clinical Proteomics 2018 15:5

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  24. Content type: Letter to the Editor

    The Human Cancer Proteome Project (Cancer-HPP) is an international initiative organized by HUPO whose key objective is to decipher the human cancer proteome through a coordinated effort by cancer proteome rese...

    Authors: Connie R. Jimenez, Hui Zhang, Christopher R. Kinsinger and Edouard C. Nice

    Citation: Clinical Proteomics 2018 15:4

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  25. Content type: Review

    There has been tremendous progress in detection of breast cancer in postmenopausal women, resulting in two-thirds of women surviving more than 20 years after treatment. However, breast cancer remains the leadi...

    Authors: Sadr-ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Richard Linforth, Mohamed Salhab and Chris Sutton

    Citation: Clinical Proteomics 2018 15:3

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  26. Content type: Research

    Staphylococcus aureus (S. aureus or SA) is a leading cause of healthcare-associated (HA-) and community-associated (CA) infection. HA-SA isolates usually cause nosocomial pneumonia, bloodstream infections, cathet...

    Authors: Lei He, Hongwei Meng, Qian Liu, Mo Hu, Yanan Wang, Xiaoying Chen, Xiaoyun Liu and Min Li

    Citation: Clinical Proteomics 2018 15:2

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  27. Content type: Research

    Nontuberculous mycobacteria (NTM)-mediated infections are a growing cause of worldwide morbidity, but lack of rapid diagnostics for specific NTM species can delay the initiation of appropriate treatment regime...

    Authors: Wei Zhang, Qingbo Shu, Zhen Zhao, Jia Fan, Christopher J. Lyon, Adrian M. Zelazny and Ye Hu

    Citation: Clinical Proteomics 2018 15:1

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  28. Content type: Research

    Normal human EDTA plasma samples were collected on ice, processed ice cold, and stored in a freezer at – 80 °C prior to experiments. Plasma test samples from the – 80 °C freezer were thawed on ice or intention...

    Authors: Jaimie Dufresne, Angelique Florentinus-Mefailoski, Juliet Ajambo, Ammara Ferwa, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:41

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  29. Content type: Research

    Vulvar squamous cell carcinoma (vSCC) is a rare but debilitating disease. One vSCC variant comprises tumor cells that grow and expand as a cohesive sheet of cells that “pushes” and compresses the associated ly...

    Authors: Emily R. Holthoff, Stephanie D. Byrum, Samuel G. Mackintosh, Thomas Kelly, Alan J. Tackett, Charles M. Quick and Steven R. Post

    Citation: Clinical Proteomics 2017 14:40

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  30. Content type: Research

    The tryptic peptides from ice cold versus room temperature plasma were identified by C18 liquid chromatography and micro electrospray ionization tandem mass spectrometry (LC–ESI–MS/MS). Samples collected on ic...

    Authors: Jaimie Dufresne, Angelique Florentinus-Mefailoski, Juliet Ajambo, Ammara Ferwa, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:39

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  31. Content type: Research

    It is well known that fibrin network binds a large variety of proteins, including inhibitors and activators of fibrinolysis, which may affect clot properties, such as stability and susceptibility to fibrinolys...

    Authors: Aneta Stachowicz, Jakub Siudut, Maciej Suski, Rafał Olszanecki, Ryszard Korbut, Anetta Undas and Jacek R. Wiśniewski

    Citation: Clinical Proteomics 2017 14:38

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  32. Content type: Research

    Idiopathic macular holes (IMH) are full-thickness defects of retinal tissue that cause severe vision loss due to disruption of the anatomic fovea. Abnormal vitreous traction is involved in the formation of mac...

    Authors: Pingbo Zhang, Min Zhu, Yuming Zhao, Jiang Qian, Craig Dufresne, Randi Turner, Richard D. Semba and Sharon D. Solomon

    Citation: Clinical Proteomics 2017 14:37

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  33. Content type: Research

    Bovine purified protein derivative (bPPD) and avian purified protein derivative (aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about their qualitative and quantitative chara...

    Authors: José Antonio Infantes-Lorenzo, Inmaculada Moreno, María de los Ángeles Risalde, Álvaro Roy, Margarita Villar, Beatriz Romero, Nieves Ibarrola, José de la Fuente, Eugenia Puentes, Lucía de Juan, Christian Gortázar, Javier Bezos, Lucas Domínguez and Mercedes Domínguez

    Citation: Clinical Proteomics 2017 14:36

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  34. Content type: Research

    Thirty human EDTA plasma samples from male and female subjects ranging in age from 24 to 74 years were collected on ice, processed ice cold and stored frozen at −80 °C, in liquid nitrogen (LN2), or freeze dri...

    Authors: Jaimie Dufresne, Trung Hoang, Juliet Ajambo, Angelique Florentinus-Mefailoski, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:35

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  35. Content type: Research

    Currently, there are no FDA approved screening tools for detecting early stage ovarian cancer in the general population. Development of a biomarker-based assay for early detection would significantly improve t...

    Authors: Kristin L. M. Boylan, Kate Geschwind, Joseph S. Koopmeiners, Melissa A. Geller, Timothy K. Starr and Amy P. N. Skubitz

    Citation: Clinical Proteomics 2017 14:34

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  36. Content type: Research

    Cancer associated fibroblasts are activated in the tumor microenvironment and contribute to tumor progression, angiogenesis, extracellular matrix remodeling, and inflammation.

    Authors: Daniel Drev, Andrea Bileck, Zeynep N. Erdem, Thomas Mohr, Gerald Timelthaler, Andrea Beer, Christopher Gerner and Brigitte Marian

    Citation: Clinical Proteomics 2017 14:33

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  37. Content type: Research

    Systemic lupus erythematosus (SLE) is a remarkably heterogeneous autoimmune disease. Despite tremendous efforts, our knowledge of serum protein patterns in severe SLE phenotypes is still limited. We investigat...

    Authors: Anna Petrackova, Andrea Smrzova, Petr Gajdos, Marketa Schubertova, Petra Schneiderova, Pavel Kromer, Vaclav Snasel, Martina Skacelova, Frantisek Mrazek, Josef Zadrazil, Pavel Horak and Eva Kriegova

    Citation: Clinical Proteomics 2017 14:32

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  38. Content type: Research

    Non-small cell lung carcinoma (NSCLC) remains the leading cause of cancer deaths in the United States. More than half of NSCLC patients have clinical presentations with locally advanced or metastatic disease a...

    Authors: Shuang Yang, Lijun Chen, Daniel W. Chan, Qing Kay Li and Hui Zhang

    Citation: Clinical Proteomics 2017 14:31

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  39. Content type: Research

    The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with pro...

    Authors: Teodora Ioana Flavia Paunas, Kenneth Finne, Sabine Leh, Hans-Peter Marti, Tom Eirik Mollnes, Frode Berven and Bjørn Egil Vikse

    Citation: Clinical Proteomics 2017 14:30

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  40. Content type: Research

    Hepatocellular carcinoma is an aggressive malignancy with poor prognosis and easy to recur even the tumor is totally removed by surgery. Portal vascular invasion is one of the major factors contributing to tum...

    Authors: Wei-Chen Lee, Hong-Shiue Chou, Ting-Jung Wu, Chen-Fang Lee, Pao-Yueh Hsu, Hsiu-Ying Hsu, Tsung-Han Wu and Kun-Ming Chan

    Citation: Clinical Proteomics 2017 14:29

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  41. Content type: Research

    The aim was to improve upon an existing blood-based colorectal cancer (CRC) test directed to high-risk symptomatic patients, by developing a new CRC classifier to be used with a new test embodiment. The new te...

    Authors: Lisa J. Croner, Roslyn Dillon, Athit Kao, Stefanie N. Kairs, Ryan Benz, Ib J. Christensen, Hans J. Nielsen, John E. Blume and Bruce Wilcox

    Citation: Clinical Proteomics 2017 14:28

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  42. Content type: Research

    Post-stroke infections occur in 20–36% of stroke patients and are associated with high morbidity and mortality rates. Early identification of patients at risk of developing an infection could improve care via ...

    Authors: L. Azurmendi, V. Lapierre-Fetaud, J. Schneider, J. Montaner, M. Katan and Jean-Charles Sanchez

    Citation: Clinical Proteomics 2017 14:27

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  43. Content type: Research

    Mesenchymal stem/stromal cells (MSC) display a range of immunoregulatory properties which can be enhanced by the exposure to cytokines such interferon γ (IFN-γ). However the compositional changes associated wi...

    Authors: Qingdong Guan, Peyman Ezzati, Victor Spicer, Oleg Krokhin, Donna Wall and John A. Wilkins

    Citation: Clinical Proteomics 2017 14:26

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  44. Content type: Research

    The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screenin...

    Authors: Charles E. Birse, Jennifer L. Tomic, Harvey I. Pass, William N. Rom and Robert J. Lagier

    Citation: Clinical Proteomics 2017 14:25

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  45. Content type: Research

    The pathogenesis of systemic lupus erythematosus (SLE) is poorly understood but has been linked to defective clearance of subcellular particulate material from the circulation. This study investigates the orig...

    Authors: Ole Østergaard, Christoffer Tandrup Nielsen, Julia T. Tanassi, Line V. Iversen, Søren Jacobsen and Niels H. H. Heegaard

    Citation: Clinical Proteomics 2017 14:23

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  46. Content type: Research

    Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding...

    Authors: Regent Lee, Roman Fischer, Philip D. Charles, David Adlam, Alessandro Valli, Katalin Di Gleria, Rajesh K. Kharbanda, Robin P. Choudhury, Charalambos Antoniades, Benedikt M. Kessler and Keith M. Channon

    Citation: Clinical Proteomics 2017 14:22

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  47. Content type: Research

    Mycobacterium tuberculosis (Mtb) is the causative agent of Tuberculosis (TB), the number one cause of death due to an infectious disease. TB diagnosis is performed by microscopy, cultu...

    Authors: Carolina Mehaffy, Karen M. Dobos, Payam Nahid and Nicole A. Kruh-Garcia

    Citation: Clinical Proteomics 2017 14:21

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  48. Content type: Research

    Ovarian cancer is one of the most lethal gynecological malignancies, in which platinum resistance is a common cause of its relapse and death. Glycosylation has been reported to be involved in drug resistance, ...

    Authors: Ran Zhao, Wenjun Qin, Ruihuan Qin, Jing Han, Can Li, Yisheng Wang and Congjian Xu

    Citation: Clinical Proteomics 2017 14:20

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  49. Content type: Research

    The Xiaoke Pill containing Chinese herb extracts and Glibenclamide, is used in therapy for type 2 diabetes mellitus (T2DM), and is effective in reducing the risk of hypoglycemia and improving diabetes symptoms...

    Authors: Xiuying Zhang, Haidan Sun, Sanjoy K. Paul, Quanhui Wang, Xiaomin Lou, Guixue Hou, Bo Wen, Linong Ji and Siqi Liu

    Citation: Clinical Proteomics 2017 14:19

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