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  1. One of the most significant challenges in colorectal cancer (CRC) management is the use of compliant early stage population-based diagnostic tests as adjuncts to confirmatory colonoscopy. Despite the near cura...

    Authors: Seong Beom Ahn, Samridhi Sharma, Abidali Mohamedali, Sadia Mahboob, William J. Redmond, Dana Pascovici, Jemma X. Wu, Thiri Zaw, Subash Adhikari, Vineet Vaibhav, Edouard C. Nice and Mark S. Baker

    Citation: Clinical Proteomics 2019 16:34

    Content type: Research

    Published on:

  3. Bone marrow stromal cells protect hematopoietic cells and provide drug resistance by delivering bunch of variable proteins. Thus, alterations of protein expression are typically associated with cell–cell signa...

    Authors: Rui Liu, Yi Wang, Bingxin Li, Hui Wang, Feng Guan, Zengqi Tan and Xiang Li

    Citation: Clinical Proteomics 2019 16:32

    Content type: Research

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  4. Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer that is characterized by its poor prognosis, rapid progression and development of drug resistance. Chemotherapy is a vital treatment option for most o...

    Authors: Hong Peng, Ru Chen, Teresa A. Brentnall, Jimmy K. Eng, Vincent J. Picozzi and Sheng Pan

    Citation: Clinical Proteomics 2019 16:31

    Content type: Research

    Published on:

  5. In the original version of the article [1], an error was noticed under the heading “Immunoprecipitation on protein G magnetic beads” in “Methods” section.

    Authors: Milena Music, Antoninus Soosaipillai, Ihor Batruch, Ioannis Prassas, Dimitrios P. Bogdanos and Eleftherios P. Diamandis

    Citation: Clinical Proteomics 2019 16:30

    Content type: Correction

    Published on:

    The original article was published in Clinical Proteomics 2019 16:25

  6. Sepsis is a dysregulated host response to infection and a major cause of death worldwide. Respiratory tract infections account for most sepsis cases and depending on the place of acquisition, i.e., community o...

    Authors: Narendra Kumar Sharma, Bianca Lima Ferreira, Alexandre Keiji Tashima, Milena Karina Colo Brunialti, Ricardo Jose Soares Torquato, Antonio Bafi, Murillo Assuncao, Luciano Cesar Pontes Azevedo and Reinaldo Salomao

    Citation: Clinical Proteomics 2019 16:29

    Content type: Research

    Published on:

  7. Chronic pelvic pain is often overlooked during primary examinations because of the numerous causes of such “vague” symptoms. However, this pain can often mask endometriosis, a smoldering disease that is not ea...

    Authors: Bao Weisheng, Ceana H. Nezhat, Gordon F. Huang, Ying-Qing Mao, Neil Sidell and Ruo-Pan Huang

    Citation: Clinical Proteomics 2019 16:28

    Content type: Research

    Published on:

  8. In the version of this article that was originally published [1], some information in the “Acknowledgements” section was omitted.

    Authors: Jingi Bae, Su-Jin Kim, Seung-Eun Lee, Wooil Kwon, Hongbeom Kim, Youngmin Han, Jin-Young Jang, Min-Sik Kim and Sang-Won Lee

    Citation: Clinical Proteomics 2019 16:27

    Content type: Correction

    Published on:

    The original article was published in Clinical Proteomics 2019 16:18

  9. This proof of concept study was aimed at characterizing novel salivary biomarkers specific for different subsets in primary Sjögren’s syndrome (pSS) in order to improve patients’ profiling.

    Authors: Antonella Cecchettini, Francesco Finamore, Nadia Ucciferri, Valentina Donati, Letizia Mattii, Enza Polizzi, Francesco Ferro, Francesca Sernissi, Marta Mosca, Stefano Bombardieri, Silvia Rocchiccioli and Chiara Baldini

    Citation: Clinical Proteomics 2019 16:26

    Content type: Research

    Published on:

  10. Autoantibodies are produced when tolerance to self-antigens is broken and they can be mediators of tissue injury and systemic inflammation. They are excellent biomarkers because they are minimally invasive to ...

    Authors: Milena Music, Antoninus Soosaipillai, Ihor Batruch, Ioannis Prassas, Dimitrios P. Bogdanos and Eleftherios P. Diamandis

    Citation: Clinical Proteomics 2019 16:25

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical Proteomics 2019 16:30

  11. Although sperm cryopreservation has been widely used in human reproductive medicine as an integral infertility management in infertility clinics and for banking sperm in sperm banks, the freezing/thawing proto...

    Authors: Shanshan Li, Lei Ao, Yaping Yan, Jiang Jiang, Bingbing Chen, Yanchao Duan, Fei Shen, Jinbao Chen, Briauna Inglis, Renmin Ni, Weizhi Ji and Wei Si

    Citation: Clinical Proteomics 2019 16:24

    Content type: Research

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  12. Inflammatory arthritis (IA) is an immunological disorder in which loss of immune tolerance to endogenous self-antigens perpetuates synovitis and eventual destruction of the underlying cartilage and bone. Patho...

    Authors: Shalini M. Mahendran, Edward C. Keystone, Roman J. Krawetz, Kun Liang, Eleftherios P. Diamandis and Vinod Chandran

    Citation: Clinical Proteomics 2019 16:23

    Content type: Research

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  13. Chinese Bama Yao Autonomous County is a well-known longevity region in the world. In the past 30 years, population and genome studies were undertaken to investigate the secret of longevity and showed that long...

    Authors: Shengliang Ye, Li Ma, Rong Zhang, Fengjuan Liu, Peng Jiang, Jun Xu, Haijun Cao, Xi Du, Fangzhao Lin, Lu Cheng, Xuefeng Zhou, Zhihui Shi, Yeheng Liu, Yaojin Huang, Zongkui Wang and Changqing Li

    Citation: Clinical Proteomics 2019 16:22

    Content type: Research

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  14. Cadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations b...

    Authors: Yan Borné, Björn Fagerberg, Gerd Sallsten, Bo Hedblad, Margaretha Persson, Olle Melander, Jan Nilsson, Marju Orho-Melander, Lars Barregard and Gunnar Engström

    Citation: Clinical Proteomics 2019 16:21

    Content type: Research

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  15. Lung cancer is the leading cause of cancer death in China and around the world. Early detection is key to improving the survival rate of non-small cell lung cancer (NSCLC). Alteration in glycosylation has been...

    Authors: Yiqian Liang, Peng Han, Ting Wang, Hui Ren, Lei Gao, Puyu Shi, Shuo Zhang, Aimin Yang, Zheng Li and Mingwei Chen

    Citation: Clinical Proteomics 2019 16:20

    Content type: Research

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  16. Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. However, T cells play a central role in the pathogenesis by crossing the blood–brain-barrier, leading to inflammat...

    Authors: Tone Berge, Anna Eriksson, Ina Skaara Brorson, Einar August Høgestøl, Pål Berg-Hansen, Anne Døskeland, Olav Mjaavatten, Steffan Daniel Bos, Hanne F. Harbo and Frode Berven

    Citation: Clinical Proteomics 2019 16:19

    Content type: Research

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  17. Certain tumors such as pancreatic ductal adenocarcinoma (PDAC) are known to contain a variety of hydrolytic enzymes including RNases and proteases that may lead to degradation of RNA and proteins during sample...

    Authors: Jingi Bae, Su-Jin Kim, Seung-Eun Lee, Wooil Kwon, Hongbeom Kim, Youngmin Han, Jin-Young Jang, Min-Sik Kim and Sang-Won Lee

    Citation: Clinical Proteomics 2019 16:18

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical Proteomics 2019 16:27

  18. The bone marrow microenvironment provides an optimal substrate for multiple myeloma (MM) initiation and progression. The soluble component of MM niche is dynamic with the disease states of MM. We formerly emp...

    Authors: Ju Bai, Yun Yang, Jianli Wang, Lei Zhang, Fangxia Wang and Aili He

    Citation: Clinical Proteomics 2019 16:17

    Content type: Research

    Published on:

  19. Blood-based protein measurement is a routine practice for detecting biomarkers in human disease. Comprehensive profiling of blood/plasma/serum proteome is a challenge due to an extremely large dynamic range, a...

    Authors: Kaushik Kumar Dey, Hong Wang, Mingming Niu, Bing Bai, Xusheng Wang, Yuxin Li, Ji-Hoon Cho, Haiyan Tan, Ashutosh Mishra, Anthony A. High, Ping-Chung Chen, Zhiping Wu, Thomas G. Beach and Junmin Peng

    Citation: Clinical Proteomics 2019 16:16

    Content type: Research

    Published on:

  20. Prostate cancer (PCa) is the most frequently diagnosed non-skin cancer and a leading cause of mortality among males in developed countries. However, our understanding of the global changes of protein complexes...

    Authors: Bo Zhou, Yiwu Yan, Yang Wang, Sungyong You, Michael R. Freeman and Wei Yang

    Citation: Clinical Proteomics 2019 16:15

    Content type: Research

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  21. Endometriosis is a common gynaecological disorder affecting 5–10% of women of reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis is through laparoscopy, exposing pa...

    Authors: Stella Irungu, Dimitrios Mavrelos, Jenny Worthington, Oleg Blyuss, Ertan Saridogan and John F. Timms

    Citation: Clinical Proteomics 2019 16:14

    Content type: Research

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  22. Prostate-specific antigen (PSA) is commonly used as a serum biomarker for the detection of prostate cancer. However, levels of PSA in serum do not reliably distinguish aggressive prostate cancer from non-aggre...

    Authors: Ce Wang, Naseruddin Höti, Tung-Shing Mamie Lih, Lori J. Sokoll, Rui Zhang, Zhen Zhang, Hui Zhang and Daniel W. Chan

    Citation: Clinical Proteomics 2019 16:13

    Content type: Research

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  23. Esophageal cancer (EC) is one of the malignant tumors with a poor prognosis. The early stage of EC is asymptomatic, so identification of cancer biomarkers is important for early detection and clinical practice.

    Authors: Yanping Zhu, Xiaoying Qi, Cuicui Yu, Shoujun Yu, Chao Zhang, Yuan Zhang, Xiuxiu Liu, Yuxue Xu, Chunhua Yang, Wenguo Jiang, Geng Tian, Xuri Li, Jonas Bergquist, Jiandi Zhang, Lei Wang and Jia Mi

    Citation: Clinical Proteomics 2019 16:12

    Content type: Research

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  24. Prevalence of many eye and ocular surface diseases increases with age. While the clinical characteristics and pathophysiologic mechanisms of these conditions are often either known or extensively studied, the ...

    Authors: Janika Nättinen, Antti Jylhä, Ulla Aapola, Petri Mäkinen, Roger Beuerman, Juhani Pietilä, Anu Vaajanen and Hannu Uusitalo

    Citation: Clinical Proteomics 2019 16:11

    Content type: Research

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  26. Cerebrospinal fluid (CSF) is in direct contact with the central nervous system. This makes human CSF an attractive source of potential biomarkers for neurologic diseases. Similarly to blood plasma, proteomic a...

    Authors: Eliska Jankovska, Marek Svitek, Karel Holada and Jiri Petrak

    Citation: Clinical Proteomics 2019 16:9

    Content type: Research

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  27. Colistin (polymyxin E) and polymixin B are important bactericidal antibiotics used in the treatment of serious infections caused by multi-drug resistant Gram-negative organisms. Transferrable plasmid-mediated ...

    Authors: Honghui Wang, Yong Chen, Jeffrey R. Strich, Steven K. Drake, Jung-Ho Youn, Avi Z. Rosenberg, Marjan Gucek, Patrick T. McGann, Anthony F. Suffredini and John P. Dekker

    Citation: Clinical Proteomics 2019 16:8

    Content type: Research

    Published on:

  28. In-depth examination of the plasma proteomic response to infection with a wide variety of pathogens can assist in the development of new diagnostic paradigms, while providing insight into the interdependent pa...

    Authors: Michael D. Ward, Ernst E. Brueggemann, Tara Kenny, Raven E. Reitstetter, Christopher R. Mahone, Sylvia Trevino, Kelly Wetzel, Ginger C. Donnelly, Cary Retterer, Robert B. Norgren Jr., Rekha G. Panchal, Travis K. Warren, Sina Bavari and Lisa H. Cazares

    Citation: Clinical Proteomics 2019 16:7

    Content type: Research

    Published on:

  29. Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease. IPF is characterized by excessive accumulation of the extracellular matrix (ECM) in the alveolar parenchyma and progressive lung ...

    Authors: Yaqiong Tian, Hui Li, Yujuan Gao, Chuanmei Liu, Ting Qiu, Hongyan Wu, Mengshu Cao, Yingwei Zhang, Hui Ding, Jingyu Chen and Hourong Cai

    Citation: Clinical Proteomics 2019 16:6

    Content type: Research

    Published on:

  30. It is difficult to distinguish benign pulmonary nodules (PNs) from malignant PNs by conventional examination. Therefore, novel biomarkers that can identify the nature of PNs are needed. Exosomes have recently ...

    Authors: Muyu Kuang, Xiaoting Tao, Yizhou Peng, Wenjing Zhang, Yafang Pan, Lei Cheng, Chongze Yuan, Yue Zhao, Hengyu Mao, Lingdun Zhuge, Zhenhua Zhou, Haiquan Chen and Yihua Sun

    Citation: Clinical Proteomics 2019 16:5

    Content type: Research

    Published on:

  31. Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The cause and the pathophysiology of the disease are not fully understood and we therefor aim in this study to identify important pathop...

    Authors: Armin Schniers, Rasmus Goll, Yvonne Pasing, Sveinung Wergeland Sørbye, Jon Florholmen and Terkel Hansen

    Citation: Clinical Proteomics 2019 16:4

    Content type: Research

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  32. Biomarkers are urgently required to support current histological staging to provide additional accuracy in stratifying colorectal cancer (CRC) patients according to risk of spread to properly assign adjuvant c...

    Authors: Chandra Kirana, Lifeng Peng, Rose Miller, John P. Keating, Corinne Glenn, Hongjun Shi, T. William Jordan, Guy J. Maddern and Richard S. Stubbs

    Citation: Clinical Proteomics 2019 16:3

    Content type: Research

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  33. The biomarkers alpha-fetoprotein (AFP) and protein induced by vitamin K absence/antagonist-II (PIVKA-II) may be useful for detecting early-stage hepatocellular carcinoma (HCC). We evaluated the performance of ...

    Authors: Philip M. Hemken, Lori J. Sokoll, Xiaoqing Yang, Jianliang Dai, Debra Elliott, Susan H. Gawel, Michael Lucht, Ziding Feng, Jorge A. Marrero, Sudhir Srivastava, Daniel W. Chan and Gerard J. Davis

    Citation: Clinical Proteomics 2019 16:2

    Content type: Research

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  34. Misdiagnosis of autoimmune pancreatitis (AIP) as pancreatic cancer (PDAC) or vice versa can cause dismal patents’ outcomes. Changes in IgG glycosylation are associated with cancers and autoimmune diseases. Thi...

    Authors: Hsi-Chang Shih, Ming-Chu Chang, Chein-Hung Chen, I-Lin Tsai, San-Yuan Wang, Ya-Po Kuo, Chung-Hsuan Chen and Yu-Ting Chang

    Citation: Clinical Proteomics 2019 16:1

    Content type: Research

    Published on:

  35. Cytauxzoonosis is a disease of felids in North America caused by the tick-transmitted apicomplexan parasite Cytauxzoon felis. Cytauxzoonosis is particularly virulent for domestic cats, but no vaccine currently ex...

    Authors: Megan E. Schreeg, Henry S. Marr, Jaime L. Tarigo, Meredith K. Sherrill, Hilton K. Outi, Elizabeth H. Scholl, David M. Bird, Adam Vigil, Chris Hung, Rie Nakajima, Li Liang, Angela Trieu, Denise L. Doolan, Jennifer E. Thomas, Michael G. Levy, Mason V. Reichard…

    Citation: Clinical Proteomics 2018 15:44

    Content type: Research

    Published on:

  36. Rapid identification of novel targets and advancement of a vascular targeting strategy requires a comprehensive assessment of AVM endothelial membrane protein changes in response to irradiation. The aim of thi...

    Authors: Margaret Simonian, Dyna Shirasaki, Vivienne S. Lee, David Bervini, Michael Grace, Rachel R. Ogorzalek Loo, Joseph A. Loo, Mark P. Molloy and Marcus A. Stoodley

    Citation: Clinical Proteomics 2018 15:43

    Content type: Research

    Published on:

  38. It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma by using liquid chromatography and tandem mass spectrometry to identify, quantify and compare the peptides cl...

    Authors: Jaimie Dufresne, Pete Bowden, Thanusi Thavarajah, Angelique Florentinus-Mefailoski, Zhuo Zhen Chen, Monika Tucholska, Tenzin Norzin, Margaret Truc Ho, Morla Phan, Nargiz Mohamed, Amir Ravandi, Eric Stanton, Arthur S. Slutsky, Claudia C. dos Santos, Alexander Romaschin, John C. Marshall…

    Citation: Clinical Proteomics 2018 15:41

    Content type: Research

    Published on:

  39. Talaromyces marneffei (TM) is an emerging pathogenic fungus that can cause a fatal systemic mycosis in patients infected with human immunodeficiency virus (HIV). Although global awareness regarding HIV/TM coinfec...

    Authors: Yahong Chen, Aiqiong Huang, Wen Ao, Zhengwu Wang, Jinjin Yuan, Qing Song, Dahai Wei and Hanhui Ye

    Citation: Clinical Proteomics 2018 15:40

    Content type: Research

    Published on:

  40. It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma using LC–ESI–MS/MS to identify, quantify and compare the statistical distributions of peptides cleaved ex viv...

    Authors: Jaimie Dufresne, Pete Bowden, Thanusi Thavarajah, Angelique Florentinus-Mefailoski, Zhuo Zhen Chen, Monika Tucholska, Tenzin Norzin, Margaret Truc Ho, Morla Phan, Nargiz Mohamed, Amir Ravandi, Eric Stanton, Arthur S. Slutsky, Claudia C. dos Santos, Alexander Romaschin, John C. Marshall…

    Citation: Clinical Proteomics 2018 15:39

    Content type: Research

    Published on:

  41. Over 500,000 women worldwide are diagnosed with ovarian or endometrial cancer each year. We have used a two-step strategy to identify plasma proteins that could be used to improve the diagnosis of women with a...

    Authors: Stefan Enroth, Malin Berggrund, Maria Lycke, Martin Lundberg, Erika Assarsson, Matts Olovsson, Karin Stålberg, Karin Sundfeldt and Ulf Gyllensten

    Citation: Clinical Proteomics 2018 15:38

    Content type: Research

    Published on:

  42. Unfortunately, after publication of this article [1], errors were noticed in Figs. 3 and 4.

    Authors: Xinyan Wu, Muhammad Saddiq Zahari, Santosh Renuse, Nandini A. Sahasrabuddhe, Raghothama Chaerkady, Mi-Sik Kim, Mary Jo Fackler, Martha Stampfer, Edward Gabrielson, Saraswati Sukumar and Akhilesh Pandey

    Citation: Clinical Proteomics 2018 15:37

    Content type: Correction

    Published on:

    The original article was published in Clinical Proteomics 2018 15:21

  43. Natural menopause is always accompanied by specific signs and symptoms, suggesting physiological changes in this peoriod. However, no systematic study has assessed the changes at molecular level in the ovaries...

    Authors: Jinling Yi, Huatianshu Hu, Peipei Shi, Song Shi, Junda Zhao, Linna Xu, Weining Yang, Bin Li, Jin Zhu and Shien Zou

    Citation: Clinical Proteomics 2018 15:36

    Content type: Research

    Published on:

  44. Current risk prediction models in heart failure (HF) including clinical characteristics and biomarkers only have moderate predictive value. The aim of this study was to use matrix assisted laser desorption ion...

    Authors: Thong Huy Cao, Donald J. L. Jones, Paulene A. Quinn, Daniel Chu Siong Chan, Narayan Hafid, Helen M. Parry, Mohapradeep Mohan, Jatinderpal K. Sandhu, Stefan D. Anker, John G. Cleland, Kenneth Dickstein, Gerasimos Filippatos, Hans L. Hillege, Marco Metra, Piotr Ponikowski, Nilesh J. Samani…

    Citation: Clinical Proteomics 2018 15:35

    Content type: Research

    Published on:

  45. Duchenne muscular dystrophy is a highly complex multi-system disease caused by primary abnormalities in the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle degeneration, this neur...

    Authors: Sandra Murphy, Margit Zweyer, Michael Henry, Paula Meleady, Rustam R. Mundegar, Dieter Swandulla and Kay Ohlendieck

    Citation: Clinical Proteomics 2018 15:34

    Content type: Research

    Published on:

  48. Although total plasma lipoproteome consists of proteins that have shown promises as biomarkers that can identify Alzheimer’s disease (AD), effect sizes are modest. The objective of this study is to provide ini...

    Authors: Danni Li, Fangying Huang, Yingchun Zhao, Peter W. Villata, Timothy J. Griffin, Lin Zhang, Ling Li and Fang Yu

    Citation: Clinical Proteomics 2018 15:31

    Content type: Research

    Published on:

  49. In recent years, there has been an emphasis on personalizing breast cancer treatment in order to avoid the debilitating side effects caused by broad-spectrum chemotherapeutic drug treatment. Development of per...

    Authors: Yvonne S. Ziegler, James J. Moresco, Patricia G. Tu, John R. Yates III and Ann M. Nardulli

    Citation: Clinical Proteomics 2018 15:30

    Content type: Letter to the Editor

    Published on:

  50. Cerebrospinal fluid (CSF) is an important source of potential biomarkers that affect the brain. Biomarkers for neurodegenerative disorders are needed to assist in diagnosis, monitoring disease progression and ...

    Authors: Gajanan Sathe, Chan Hyun Na, Santosh Renuse, Anil Madugundu, Marilyn Albert, Abhay Moghekar and Akhilesh Pandey

    Citation: Clinical Proteomics 2018 15:29

    Content type: Research

    Published on:

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ISSN: 1559-0275