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  1. The early identification of patients at high-risk for end-stage renal disease (ESRD) is essential for providing optimal care and implementing targeted prevention strategies. While the Kidney Failure Risk Equat...

    Authors: Carlos Raúl Ramírez Medina, Ibrahim Ali, Ivona Baricevic-Jones, Moin A. Saleem, Anthony D. Whetton, Philip A. Kalra and Nophar Geifman
    Citation: Clinical Proteomics 2024 21:34
  2. COVID-19 is a complex, multi-system disease with varying severity and symptoms. Identifying changes in critically ill COVID-19 patients’ proteomes enables a better understanding of markers associated with susc...

    Authors: Maitray A. Patel, Mark Daley, Logan R. Van Nynatten, Marat Slessarev, Gediminas Cepinskas and Douglas D. Fraser
    Citation: Clinical Proteomics 2024 21:33
  3. Traumatic brain injury (TBI) often results in diverse molecular responses, challenging traditional proteomic studies that measure average changes at tissue levels and fail to capture the complexity and heterog...

    Authors: Sudipa Maity, Yuanyu Huang, Mitchell D. Kilgore, Abbigail N. Thurmon, Lee O. Vaasjo, Maria J. Galazo, Xiaojiang Xu, Jing Cao, Xiaoying Wang, Bo Ning, Ning Liu and Jia Fan
    Citation: Clinical Proteomics 2024 21:32
  4. Authors: Tomonori Kaneko, Sally Ezra, Rober Abdo, Courtney Voss, Shanshan Zhong, Xuguang Liu, Owen Hovey, Marat Slessarev, Logan Robert Van Nynatten, Mingliang Ye, Douglas D. Fraser and Shawn Shun‑Cheng Li
    Citation: Clinical Proteomics 2024 21:31

    The original article was published in Clinical Proteomics 2020 17:1

  5. Cardio-metabolic disorders (CMDs) are common in aging people and are pivotal risk factors for cardiovascular diseases (CVDs). Inflammation is involved in the pathogenesis of CVDs and aging, but the underlying ...

    Authors: Siting Wu, Yulin Li, Xue Zhao, Fu-Dong Shi and Jingshan Chen
    Citation: Clinical Proteomics 2024 21:30
  6. Adamantinomatous craniopharyngiomas (ACPs) are rare benign epithelial tumours with high recurrence and poor prognosis. Biological differences between recurrent and primary ACPs that may be associated with dise...

    Authors: Haidong Deng, Ting Lei, Siqi Liu, Wenzhe Hao, Mengqing Hu, Xin Xiang, Ling Ye, Dongting Chen, Yan Li and Fangjun Liu
    Citation: Clinical Proteomics 2024 21:29
  7. Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) exhibit serum autoantibodies against aquapori...

    Authors: Miyo K. Chatanaka, Lisa M. Avery, Maria D. Pasic, Shanthan Sithravadivel, Dalia Rotstein, Catherine Demos, Rachel Cohen, Taron Gorham, Mingyue Wang, Martin Stengelin, Anu Mathew, George Sigal, Jacob Wohlstadter, Ioannis Prassas and Eleftherios P. Diamandis
    Citation: Clinical Proteomics 2024 21:28
  8. Colorectal Cancer (CRC) is a prevalent form of cancer, and the effectiveness of the main postoperative chemotherapy treatment, FOLFOX, varies among patients. In this study, we aimed to identify potential bioma...

    Authors: Xi Wang, Keren Zhang, Wan He, Luobin Zhang, Biwei Gao, Ruijun Tian and Ruilian Xu
    Citation: Clinical Proteomics 2024 21:27
  9. Clinical samples are irreplaceable, and their transformation into searchable and reusable digital biobanks is critical for conducting statistically empowered retrospective and integrative research studies. Cur...

    Authors: Sandra Goetze, Audrey van Drogen, Jonas B. Albinus, Kyle L. Fort, Tejas Gandhi, Damiano Robbiani, Véronique Laforte, Lukas Reiter, Mitchell P. Levesque, Yue Xuan and Bernd Wollscheid
    Citation: Clinical Proteomics 2024 21:26
  10. Metastatic pancreatic adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States, with a 5-year survival rate of only 11%, necessitating identification of novel treatment par...

    Authors: Jamie Randall, Allison L. Hunt, Aratara Nutcharoen, Laura Johnston, Safae Chouraichi, Hongkun Wang, Arthur Winer, Raymond Wadlow, Jasmine Huynh, Justin Davis, Brian Corgiat, Nicholas W. Bateman, John F. Deeken, Emanuel F. Petricoin, Thomas P. Conrads and Timothy L. Cannon
    Citation: Clinical Proteomics 2024 21:24
  11. Human tear protein biomarkers are useful for detecting ocular and systemic diseases. Unfortunately, existing tear film sampling methods (Schirmer strip; SS and microcapillary tube; MCT) have significant drawba...

    Authors: Robert K. Roden, Nathan Zuniga, Joshua C. Wright, David H. Parkinson, Fangfang Jiang, Leena M. Patil, Rebecca S. Burlett, Alyssa A. Nitz, Joshua J. Rogers, Jarett T. Pittman, Kenneth L. Virgin, P. Christine Ackroyd, Samuel H. Payne, John C. Price and Kenneth A. Christensen
    Citation: Clinical Proteomics 2024 21:23
  12. Plasma proteomics holds immense potential for clinical research and biomarker discovery, serving as a non-invasive "liquid biopsy" for tissue sampling. Mass spectrometry (MS)-based proteomics, thanks to improv...

    Authors: Ines Metatla, Kevin Roger, Cerina Chhuon, Sara Ceccacci, Manuel Chapelle, Pierre-Olivier Schmit, Vadim Demichev and Ida Chiara Guerrera
    Citation: Clinical Proteomics 2024 21:22
  13. Despite progress, MS-based proteomics in biofluids, especially blood, faces challenges such as dynamic range and throughput limitations in biomarker and disease studies. In this work, we used cutting-edge prot...

    Authors: Ghaith M. Hamza, Rekha Raghunathan, Stephanie Ashenden, Bairu Zhang, Eric Miele and Andrew F. Jarnuczak
    Citation: Clinical Proteomics 2024 21:21
  14. In persons with dyslipidemia, a high residual risk of cardiovascular disease remains despite lipid lowering therapy. Current cardiovascular risk prediction mainly focuses on low-density lipoprotein cholesterol...

    Authors: Esther Reijnders, Arnoud van der Laarse, L. Renee Ruhaak and Christa M. Cobbaert
    Citation: Clinical Proteomics 2024 21:19
  15. Cardiac rupture (CR) is a rare but catastrophic mechanical complication of acute myocardial infarction (AMI) that seriously threatens human health. However, the reliable biomarkers for clinical diagnosis and t...

    Authors: Jingyuan Hou, Qiaoting Deng, Xiaohong Qiu, Sudong Liu, Youqian Li, Changjing Huang, Xianfang Wang, Qunji Zhang, Xunwei Deng, Zhixiong Zhong and Wei Zhong
    Citation: Clinical Proteomics 2024 21:18
  16. Immunotherapy is applied to breast cancer to resolve the limitations of survival gain in existing treatment modalities. With immunotherapy, a tumor can be classified into immune-inflamed, excluded and desert b...

    Authors: Yeonjin Jeon, GunHee Lee, Hwangkyo Jeong, Gyungyub Gong, JiSun Kim, Kyunggon Kim, Jae Ho Jeong and Hee Jin Lee
    Citation: Clinical Proteomics 2024 21:17
  17. Presently, antibody concentration measurements for patients undergoing treatment are predominantly determined by ELISA, which still comes with known disadvantages. Therefore, our aim was to establish a targete...

    Authors: Andreas Hentschel, Gina Piontek, Rob Dahlmann, Peter Findeisen, Roman Sakson, Phil Carbow, Thomas Renné, Yvonne Reinders and Albert Sickmann
    Citation: Clinical Proteomics 2024 21:16
  18. Hypertension is an important public health priority with a high prevalence in Africa. It is also an independent risk factor for kidney outcomes. We aimed to identify potential proteins and pathways involved in...

    Authors: Melanie A. Govender, Stoyan H. Stoychev, Jean-Tristan Brandenburg, Michèle Ramsay, June Fabian and Ireshyn S. Govender
    Citation: Clinical Proteomics 2024 21:15
  19. Serum or plasma is frequently utilized in biomedical research; however, its application is impeded by the requirement for invasive sample collection. The non-invasive nature of urine collection makes it an att...

    Authors: Neha Joshi, Kishore Garapati, Vivek Ghose, Richard K. Kandasamy and Akhilesh Pandey
    Citation: Clinical Proteomics 2024 21:14
  20. SARS-CoV-2 infection triggers extensive host immune reactions, leading to severe diseases in certain individuals. However, the molecular basis underlying the excessive yet non-productive immune responses in se...

    Authors: Tomonori Kaneko, Sally Ezra, Rober Abdo, Courtney Voss, Shanshan Zhong, Xuguang Liu, Owen Hovey, Marat Slessarev, Logan Robert Van Nynatten, Mingliang Ye, Douglas D. Fraser and Shawn Shun-Cheng Li
    Citation: Clinical Proteomics 2024 21:13
  21. Mass spectrometry (MS) assays offer exceptional capabilities in high multiplexity, specificity, and throughput. As proteomics technologies continue advancements to identify new disease biomarkers, transition o...

    Authors: Chia-Li Han, Chi-Ting Lai, Aaron James Reyes, Hao-Chin Yang, Jin-Ying Lu, Shyang-Rong Shih, Kuen-Yuan Chen, Andrew N. Hoofnagle, Sung-Liang Yu, William Bocik, Tara Hiltke, Huan-Chi Chiu, Ching-Yi Wan, Henry Rodriguez, Victoria Zhang and Yu-Ju Chen
    Citation: Clinical Proteomics 2024 21:12
  22. Small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (LASIK) are widely used surgical methods to correct myopia with comparable efficacy, predictability, and safety...

    Authors: Petri Mäkinen, Janika Nättinen, Ulla Aapola, Juhani Pietilä and Hannu Uusitalo
    Citation: Clinical Proteomics 2024 21:11
  23. COPD is a complex respiratory disorder with high morbidity and mortality rates. Even with the current conventional diagnostic methods, including circulating inflammatory biomarkers, underdiagnosis rates in COP...

    Authors: Sonu Das, Supriya Adiody, Jinsu Varghese, M Vanditha, Evelyn Maria and Mathew John
    Citation: Clinical Proteomics 2024 21:10
  24. Dynein axonemal intermediate chain 1 protein (DNAI1) plays an essential role in cilia structure and function, while its mutations lead to primary ciliary dyskinesia (PCD). Accurate quantitation of DNAI1 in lun...

    Authors: Hui Wang, Xiaoyan Ni, Nicholas Clark, Kristen Randall, Lianne Boeglin, Sudha Chivukula, Caroline Woo, Frank DeRosa and Gang Sun
    Citation: Clinical Proteomics 2024 21:8
  25. Omics characterization of pancreatic adenocarcinoma tissue is complicated by the highly heterogeneous and mixed populations of cells. We evaluate the feasibility and potential benefit of using a coring method ...

    Authors: Sara R. Savage, Yuefan Wang, Lijun Chen, Scott Jewell, Chelsea Newton, Yongchao Dou, Qing Kay Li, Oliver F. Bathe, Ana I. Robles, Gilbert S. Omenn, Mathangi Thiagarajan, Hui Zhang, Galen Hostetter and Bing Zhang
    Citation: Clinical Proteomics 2024 21:7
  26. Routine measurement of cancer biomarkers is performed for early detection, risk classification, and treatment monitoring, among other applications, and has substantially contributed to better clinical outcomes...

    Authors: Deborah Wenk, Charlotte Zuo, Thomas Kislinger and Lusia Sepiashvili
    Citation: Clinical Proteomics 2024 21:6
  27. The 2022 consensus statement of the European Atherosclerosis Society (EAS) on lipoprotein(a) (Lp(a)) recognizes the role of Lp(a) as a relevant genetically determined risk factor and recommends its measurement...

    Authors: Nina M. Diederiks, L. Renee Ruhaak, Fred P. H. T. M. Romijn, Mervin M. Pieterse, Nico P. M. Smit and Christa M. Cobbaert
    Citation: Clinical Proteomics 2024 21:5
  28. Although uterine serous carcinoma (USC) represents a small proportion of all uterine cancer cases, patients with this aggressive subtype typically have high rates of chemotherapy resistance and disease recurre...

    Authors: Allison L. Hunt, Nicholas W. Bateman, Waleed Barakat, Sasha C. Makohon-Moore, Tamara Abulez, Jordan A. Driscoll, Joshua P. Schaaf, Brian L. Hood, Kelly A. Conrads, Ming Zhou, Valerie Calvert, Mariaelena Pierobon, Jeremy Loffredo, Katlin N. Wilson, Tracy J. Litzi, Pang-Ning Teng…
    Citation: Clinical Proteomics 2024 21:4
  29. Protein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential. For breast cancer treatment, the identification and quant...

    Authors: Alexander B. Saltzman, Doug W. Chan, Matthew V. Holt, Junkai Wang, Eric J. Jaehnig, Meenakshi Anurag, Purba Singh, Anna Malovannaya, Beom-Jun Kim and Matthew J. Ellis
    Citation: Clinical Proteomics 2024 21:3
  30. Despite recent innovations in imaging and genomic screening promotes advance in diagnosis and treatment of lung adenocarcinoma (LUAD), there remains high mortality of LUAD and insufficient understanding of LUA...

    Authors: Yuqi Huang, Sheng Ma, Jun-Yu Xu, Kun Qian, Yaru Wang, Yi Zhang, Minjia Tan and Ting Xiao
    Citation: Clinical Proteomics 2024 21:2
  31. Ovarian cancer is the most lethal gynecologic malignancy in women, and high-grade serous ovarian cancer (HGSOC) is the most common subtype. Currently, no clinical test has been approved by the FDA to screen th...

    Authors: Joohyun Ryu, Kristin L. M. Boylan, Carly A. I. Twigg, Richard Evans, Amy P. N. Skubitz and Stefani N. Thomas
    Citation: Clinical Proteomics 2024 21:1
  32. Cell surface proteins perform critical functions related to immune response, signal transduction, cell–cell interactions, and cell migration. Expression of specific cell surface proteins can determine cell-typ...

    Authors: Kishore Garapati, Husheng Ding, M. Cristine Charlesworth, Yohan Kim, Roman Zenka, Mayank Saraswat, Dong-Gi Mun, Sandip Chavan, Ashish Shingade, Fabrice Lucien, Jun Zhong, Richard K. Kandasamy and Akhilesh Pandey
    Citation: Clinical Proteomics 2023 20:56
  33. Metabolic associated fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, and it is also a high-risk factor for the development of other metabolic diseases. Shenling Baizhu p...

    Authors: Sufei Song, Jixian Zheng, Dongmei Zhao, Anni Zheng, Ye Zhu, Qiuling Xu and Tao Liu
    Citation: Clinical Proteomics 2023 20:55
  34. This study investigates the proteomic landscapes of chromophobe renal cell carcinoma (chRCC) and renal oncocytomas (RO), two subtypes of renal cell carcinoma that together account for approximately 10% of all ...

    Authors: Luis B. Carvalho, Susana Jorge, Hugo López-Fernández, Carlos Lodeiro, Rajiv Dhir, Luis Campos Pinheiro, Mariana Medeiros, Hugo M. Santos and José L. Capelo
    Citation: Clinical Proteomics 2023 20:54
  35. Diagnosis of liver disease at earlier stages can improve outcomes and reduce the risk of progression to malignancy. Liver biopsy is the gold standard for diagnosis of liver disease, but is invasive and sample ...

    Authors: Philip M. Hemken, Xuzhen Qin, Lori J. Sokoll, Laurel Jackson, Fan Feng, Peng Li, Susan H. Gawel, Bailin Tu, Zhihong Lin, James Hartnett, David Hawksworth, Bryan C. Tieman, Toru Yoshimura, Hideki Kinukawa, Shaohua Ning, Enfu Liu…
    Citation: Clinical Proteomics 2023 20:53
  36. Prostate Cancer (PCa) represents the second leading cause of cancer-related death in men. Prostate-specific antigen (PSA) serum testing, currently used for PCa screening, lacks the necessary sensitivity and sp...

    Authors: Caterina Gabriele, Federica Aracri, Licia Elvira Prestagiacomo, Maria Antonietta Rota, Stefano Alba, Giuseppe Tradigo, Pietro Hiram Guzzi, Giovanni Cuda, Rocco Damiano, Pierangelo Veltri and Marco Gaspari
    Citation: Clinical Proteomics 2023 20:52
  37. The organ perfusion solution (perfusate), collected at clinically and temporally significant stages of the organ preservation and transplantation process, provides a valuable insight into the biological status...

    Authors: Corinna M. Snashall, Chris W. Sutton, Letizia Lo Faro, Carlo Ceresa, Rutger Ploeg and Sadr ul Shaheed
    Citation: Clinical Proteomics 2023 20:51
  38. Prostate cancer (PCa) is the second most common cancer in males worldwide. The risk stratification of PCa is mainly based on morphological examination. Here we analyzed the proteome of 667 tumor samples from 4...

    Authors: Rui Sun, Lingling Tan, Xuan Ding, Jun A, Zhangzhi Xue, Xue Cai, Sainan Li and Tiannan Guo
    Citation: Clinical Proteomics 2023 20:50
  39. The tyrosine kinase inhibitor sunitinib is an effective first-line treatment for patients with advanced renal cell carcinoma (RCC). Hypothesizing that a functional read-out by mass spectrometry-based (phospho, p-

    Authors: Hanneke van der Wijngaart, Robin Beekhof, Jaco C. Knol, Alex A. Henneman, Richard de Goeij-de Haas, Sander R. Piersma, Thang V. Pham, Connie R. Jimenez, Henk M. W. Verheul and Mariette Labots
    Citation: Clinical Proteomics 2023 20:49
  40. Histones posttranslational modification represent an epigenetic mechanism that regulate gene expression and other cellular processes. Quantitative mass spectrometry used for the absolute quantification of such...

    Authors: Katarzyna Macur, Andrew Schissel, Fang Yu, Shulei Lei, Brenda Morsey, Howard S. Fox and Pawel Ciborowski
    Citation: Clinical Proteomics 2023 20:48
  41. Quantification of drug-target binding is critical for confirming that drugs reach their intended protein targets, understanding the mechanism of action, and interpreting dose-response relationships. For covale...

    Authors: Andrew G. Chambers, David C. Chain, Steve M. Sweet, Zifeng Song, Philip L. Martin, Matthew J. Ellis, Claire Rooney and Yeoun Jin Kim
    Citation: Clinical Proteomics 2023 20:47
  42. Glioblastoma is one of the most malignant primary brain cancer. Despite surgical resection with modern technology followed by chemo-radiation therapy with temozolomide, resistance to the treatment and recurren...

    Authors: Narae Kang, Hyun Jeong Oh, Ji Hye Hong, Hyo Eun Moon, Yona Kim, Hyeon-Jeong Lee, Hophil Min, Hyeonji Park, Sang Hun Lee, Sun Ha Paek and Jonghwa Jin
    Citation: Clinical Proteomics 2023 20:45

    The Correction to this article has been published in Clinical Proteomics 2024 21:9

  43. The quest for understanding and managing the long-term effects of COVID-19, often referred to as Long COVID or post-COVID-19 condition (PCC), remains an active research area. Recent findings highlighted angiop...

    Authors: Eric Yamga, Antoine Soulé, Alain Piché, Amin Emad, Madeleine Durand and Simon Rousseau
    Citation: Clinical Proteomics 2023 20:44
  44. Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple organ involvement, especially the kidneys. However, the underlying mechanism remains unclear, and accurate biomarkers are still lacking...

    Authors: He Huang, Yukun Zhang, Lan Gui, Li Zhang, Minglong Cai and Yujun Sheng
    Citation: Clinical Proteomics 2023 20:43
  45. Serological diagnostics is generally defined as the detection of specific human immunoglobulins developed against viral, bacterial, or parasitic diseases. Serological tests facilitate the detection of past inf...

    Authors: Jonathan Walter, Zicki Eludin and Andrei P. Drabovich
    Citation: Clinical Proteomics 2023 20:42
  46. Meningiomas are the most prevalent primary brain tumors. Due to their increasing burden on healthcare, meningiomas have become a pivot of translational research globally. Despite many studies in the field of d...

    Authors: Ankit Halder, Deeptarup Biswas, Aparna Chauhan, Adrita Saha, Shreeman Auromahima, Deeksha Yadav, Mehar Un Nissa, Gayatri Iyer, Shashwati Parihari, Gautam Sharma, Sridhar Epari, Prakash Shetty, Aliasgar Moiyadi, Graham Roy Ball and Sanjeeva Srivastava
    Citation: Clinical Proteomics 2023 20:41

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