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  1. Content type: Letter to the Editor

    CD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion, signal transduction and cytoskeleton remodelling. It is also one of the most studied glycoproteins in cancer, frequently ex...

    Authors: Rita Azevedo, Cristiana Gaiteiro, Andreia Peixoto, Marta Relvas-Santos, Luís Lima, Lúcio Lara Santos and José Alexandre Ferreira

    Citation: Clinical Proteomics 2018 15:22

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  2. Content type: Research

    Cancer-associated fibroblasts (CAFs) are one of the most important components of tumor stroma and play a key role in modulating tumor growth. However, a mechanistic understanding of how CAFs communicate with t...

    Authors: Xinyan Wu, Muhammad Saddiq Zahari, Santosh Renuse, Nandini A. Sahasrabuddhe, Raghothama Chaerkady, Min-Sik Kim, Mary Jo Fackler, Martha Stampfer, Edward Gabrielson, Saraswati Sukumar and Akhilesh Pandey

    Citation: Clinical Proteomics 2018 15:21

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  3. Content type: Research

    Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposi...

    Authors: Neserin Ali, Stefan Ljunggren, Helen M. Karlsson, Aneta Wierzbicka, Joakim Pagels, Christina Isaxon, Anders Gudmundsson, Jenny Rissler, Jörn Nielsen, Christian H. Lindh and Monica Kåredal

    Citation: Clinical Proteomics 2018 15:20

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  4. Content type: Research

    The development of clinically accessible biomarkers is critical for the early diagnosis of gastric cancer (GC) in patients. High-throughput proteomics techniques could not only effectively generate a serum pep...

    Authors: Feiyu Shi, Hong Wu, Kai Qu, Qi Sun, Fanni Li, Chengxin Shi, Yaguang Li, Xiaofan Xiong, Qian Qin, Tianyu Yu, Xin Jin, Liang Cheng, Qingxia Wei, Yingchao Li and Junjun She

    Citation: Clinical Proteomics 2018 15:18

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  5. Content type: Research

    Semen cryopreservation has been widely applied in assisted reproductive technologies and sperm bank, but it causes considerable impairments on sperm quality. It is necessary to find an evaluation indicator for...

    Authors: Ai-jie Xin, Yan-cheng Wu, Hui Lu, Li Cheng, Yi-hua Gu, Hua Diao, Guo-wu Chen, Bin Wu, Zheng Li, Sheng-ce Tao, Xiao-xi Sun and Hui-juan Shi

    Citation: Clinical Proteomics 2018 15:19

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  6. Content type: Research

    The application of advanced imaging technologies for identifying pancreatic cysts has become widespread. However, accurately differentiating between low-grade dysplasia (LGD), high-grade dysplasia (HGD), and ...

    Authors: Misol Do, Dohyun Han, Joseph Injae Wang, Hyunsoo Kim, Wooil Kwon, Youngmin Han, Jin-Young Jang and Youngsoo Kim

    Citation: Clinical Proteomics 2018 15:17

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  7. Content type: Research

    Colorectal cancer is the third most common and the fourth most lethal cancer in the world. In the majority of cases, patients are diagnosed at an advanced stage or even metastatic, thus explaining the high mor...

    Authors: Anaïs Chauvin, Chang-Shu Wang, Sameh Geha, Perrine Garde-Granger, Alex-Ane Mathieu, Vincent Lacasse and François-Michel Boisvert

    Citation: Clinical Proteomics 2018 15:16

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  8. Content type: Research

    Colorectal cancer (CRC) remains a major cause of cancer fatalities in developed countries. The risk of death is correlated to the stage of CRC during the primary diagnosis. Early diagnosis is closely associate...

    Authors: Julien Peltier, Jean-Pierre Roperch, Stéphane Audebert, Jean-Paul Borg and Luc Camoin

    Citation: Clinical Proteomics 2018 15:15

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  9. Content type: Research

    Red blood cell (RBC) physiology is directly linked to many human disorders associated with low tissue oxygen levels or anemia including chronic obstructive pulmonary disease, congenital heart disease, sleep ap...

    Authors: Haddy K. S. Fye, Paul Mrosso, Lesley Bruce, Marie-Laëtitia Thézénas, Simon Davis, Roman Fischer, Gration L. Rwegasira, Julie Makani and Benedikt M. Kessler

    Citation: Clinical Proteomics 2018 15:14

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  10. Content type: Research

    Preoperative treatment of anti-vascular endothelial growth factor (VEGF) agents is extensively used in proliferative diabetic retinopathy (PDR), but the molecular mechanism is not fully understood. The objecti...

    Authors: Chen Zou, Changjing Han, Minjie Zhao, Jingjing Yu, Lin Bai, Yuan Yao, Shuaixin Gao, Hui Cao and Zhi Zheng

    Citation: Clinical Proteomics 2018 15:12

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  11. Content type: Research

    MAP kinase inhibitor (MAPKi) therapy for BRAF mutated melanoma is characterized by high response rates but development of drug resistance within a median progression-free survival (PFS) of 9–12 months. Underst...

    Authors: Nina Zila, Andrea Bileck, Besnik Muqaku, Lukas Janker, Ossia M. Eichhoff, Phil F. Cheng, Reinhard Dummer, Mitchell P. Levesque, Christopher Gerner and Verena Paulitschke

    Citation: Clinical Proteomics 2018 15:13

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  12. Content type: Research

    Metabolic diseases such as obesity and diabetes are associated with changes in high-density lipoprotein (HDL) particles, including changes in particle size and protein composition, often resulting in abnormal ...

    Authors: Prahlad K. Rao, Kate Merath, Eugene Drigalenko, Avinash Y. L. Jadhav, Richard A. Komorowski, Matthew I. Goldblatt, Anand Rohatgi, Mark A. Sarzynski, Samer Gawrieh and Michael Olivier

    Citation: Clinical Proteomics 2018 15:10

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  13. Content type: Research

    Proteomic analyses of clinical specimens often rely on human tissues preserved through formalin-fixation and paraffin embedding (FFPE). Minimal sample consumption is the key to preserve the integrity of pathol...

    Authors: Melanie Christine Föll, Matthias Fahrner, Victor Oginga Oria, Markus Kühs, Martin Lothar Biniossek, Martin Werner, Peter Bronsert and Oliver Schilling

    Citation: Clinical Proteomics 2018 15:11

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  14. Content type: Research

    Carcinoembryonic antigen (CEA) is a glycoprotein associated with colorectal cancer (CRC). While the functions of its gene and protein have been fully characterized, its post-translational modifications in the ...

    Authors: Qianqian Zhao, Tiancheng Zhan, Zaian Deng, Qianqian Li, Yaming Liu, Shaojie Yang, Dengbo Ji and Yan Li

    Citation: Clinical Proteomics 2018 15:9

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  15. Content type: Review

    The concept of antibody microarrays is one of the most versatile approaches within multiplexed immunoassay technologies. These types of arrays have increasingly become an attractive tool for the exploratory de...

    Authors: Ziqing Chen, Tea Dodig-Crnković, Jochen M. Schwenk and Sheng-ce Tao

    Citation: Clinical Proteomics 2018 15:7

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  16. Content type: Research

    Our previous studies indicated that miR-200b inhibits the growth of androgen-independent prostate cancer (AIPC) cells. In this study, we employed quantitative proteomics techniques to unravel the role of miR-...

    Authors: Minyi He, Mengzhuang Gou, Min Qi, Wei Xiang, Zhicheng Ji, Wen-Jie Wang, Shan-Chao Zhao and Yawei Liu

    Citation: Clinical Proteomics 2018 15:8

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  17. Content type: Research

    Scrub typhus is an acute and febrile infectious disease caused by the Gram-negative α-proteobacterium Orientia tsutsugamushi from the family Rickettsiaceae that is widely distributed in Northern, Southern and Ea...

    Authors: Edmond Changkyun Park, Sang-Yeop Lee, Sung Ho Yun, Chi-Won Choi, Hayoung Lee, Hyun Seok Song, Sangmi Jun, Gun-Hwa Kim, Chang-Seop Lee and Seung Il Kim

    Citation: Clinical Proteomics 2018 15:6

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  18. Content type: Research

    Primary membranous nephropathy (PMN) is an important cause of nephrotic syndrome in adults. Urine proteome may provide important clues of pathophysiological mechanisms in PMN. In the current study, we analyzed...

    Authors: Lu Pang, Qianqian Li, Yan Li, Yi Liu, Nan Duan and Haixia Li

    Citation: Clinical Proteomics 2018 15:5

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  19. Content type: Letter to the Editor

    The Human Cancer Proteome Project (Cancer-HPP) is an international initiative organized by HUPO whose key objective is to decipher the human cancer proteome through a coordinated effort by cancer proteome rese...

    Authors: Connie R. Jimenez, Hui Zhang, Christopher R. Kinsinger and Edouard C. Nice

    Citation: Clinical Proteomics 2018 15:4

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  20. Content type: Review

    There has been tremendous progress in detection of breast cancer in postmenopausal women, resulting in two-thirds of women surviving more than 20 years after treatment. However, breast cancer remains the leadi...

    Authors: Sadr-ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Richard Linforth, Mohamed Salhab and Chris Sutton

    Citation: Clinical Proteomics 2018 15:3

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  21. Content type: Research

    Staphylococcus aureus (S. aureus or SA) is a leading cause of healthcare-associated (HA-) and community-associated (CA) infection. HA-SA isolates usually cause nosocomial pneumonia, bloodstream infections, cathet...

    Authors: Lei He, Hongwei Meng, Qian Liu, Mo Hu, Yanan Wang, Xiaoying Chen, Xiaoyun Liu and Min Li

    Citation: Clinical Proteomics 2018 15:2

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  22. Content type: Research

    Nontuberculous mycobacteria (NTM)-mediated infections are a growing cause of worldwide morbidity, but lack of rapid diagnostics for specific NTM species can delay the initiation of appropriate treatment regime...

    Authors: Wei Zhang, Qingbo Shu, Zhen Zhao, Jia Fan, Christopher J. Lyon, Adrian M. Zelazny and Ye Hu

    Citation: Clinical Proteomics 2018 15:1

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  23. Content type: Research

    Normal human EDTA plasma samples were collected on ice, processed ice cold, and stored in a freezer at – 80 °C prior to experiments. Plasma test samples from the – 80 °C freezer were thawed on ice or intention...

    Authors: Jaimie Dufresne, Angelique Florentinus-Mefailoski, Juliet Ajambo, Ammara Ferwa, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:41

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  24. Content type: Research

    Vulvar squamous cell carcinoma (vSCC) is a rare but debilitating disease. One vSCC variant comprises tumor cells that grow and expand as a cohesive sheet of cells that “pushes” and compresses the associated ly...

    Authors: Emily R. Holthoff, Stephanie D. Byrum, Samuel G. Mackintosh, Thomas Kelly, Alan J. Tackett, Charles M. Quick and Steven R. Post

    Citation: Clinical Proteomics 2017 14:40

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  25. Content type: Research

    The tryptic peptides from ice cold versus room temperature plasma were identified by C18 liquid chromatography and micro electrospray ionization tandem mass spectrometry (LC–ESI–MS/MS). Samples collected on ic...

    Authors: Jaimie Dufresne, Angelique Florentinus-Mefailoski, Juliet Ajambo, Ammara Ferwa, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:39

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